The global chip-based oligonucleotide synthesis market, valued at USD 41.05 million in 2024, is projected to reach USD 344.36 million by 2034, growing at a CAGR of 23.7% driven by advancements in genomics, biotechnology, and personalized medicine.
Chip-based Oligonucleotide Synthesis Market Statical Scope
| Reports Attributes |
Statistics |
| Market Size in 2024 |
USD 41.05 Million |
| Market Size in 2025 |
USD 50.78 Million |
| Market Size in 2031 |
USD 181.93 Million |
| Market Size by 2034 |
USD 344.36 Million |
| CAGR 2025 to 2034 |
23.7% |
| Base Year |
2024 |
| Forecast Period |
2025 to 2034 |
The chip-based oligonucleotide synthesis market growth is driven by diagnostics and personalized medicines, next-generation sequencing and gene editing, automation & artificial intelligence AI, and RNA-based therapeutics. However, the restraining factors of the market include use of hazardous reagents, waste generation, market uncertainties, market penetration, cost constraints, quality and consistency, synthesis complexity & errors, and maintaining speed & accuracy is difficult. Regional expansion, contract services, growing demand for modified oligonucleotides, high-throughput synthesis, and advances in gene editing technologies will help the growth of the market in the future.
The chip-based oligonucleotide synthesis market is expected to grow rapidly due to the integration of artificial intelligence (AI). AI applications in chemical reactions include condition recommendations, retrosynthetic planning, and forward reaction prediction. Additionally, AI allows the automation of compound synthesis and reduces the repetitive work of laboratory staff. AI models exhibit impressive accuracy when predicting molecular properties, including toxicity, stability, and solubility.
Chip-based Oligonucleotide Synthesis Market Share, By Region, 2024 (%)
| Regions |
Shares (%) |
| North America |
40% |
| Asia Pacific |
25% |
| Europe |
30% |
| Latin America |
3% |
| Middle East & Africa |
2% |
- North America – Holds 40% of the market, being a major hub for research and development in biotechnology and pharmaceutical industries. Dominates due to its strong academic and commercial base and the continuous investment in biotechnological advancements.
- Europe – Accounts for 30% of the market, with a strong presence in scientific research and bio-manufacturing. Dominates in certain applications, particularly in medical research and diagnostics, but has slightly less growth compared to North America.
- Asia-Pacific – Captures 25% of the market, with increasing investments in biotechnology and a growing research ecosystem. Gaining momentum as biotechnology and life sciences industries expand rapidly, particularly in China and India.
- Latin America – Holds 3% of the market, with slower adoption due to less infrastructure and investment in biotechnology compared to other regions. Not dominating, but has potential for growth as research infrastructure improves.
- Middle East & Africa – Accounts for 2% of the market, with limited adoption in the oligonucleotide synthesis sector. Not dominating, as there is less emphasis on biotechnology research in this region compared to others.
Chip-based Oligonucleotide Synthesis Market Share, By Type, 2024 (%)
| Segments |
Shares (%) |
| Photochemical Method |
50% |
| Electrochemical Method |
30% |
| Inkjet Printing Method |
20% |
- Photochemical Method – Holds 50% of the market, representing the dominant method for chip-based oligonucleotide synthesis due to its widespread adoption in research and industrial applications. Dominates due to its reliability, efficiency, and established technology in the market.
- Electrochemical Method – Accounts for 30% of the market, representing a growing alternative with increasing use in precision and cost-effective synthesis. Gaining momentum due to advancements in electrochemical technology and its cost-efficiency.
- Inkjet Printing Method – Holds 20% of the market, representing a newer method for oligonucleotide synthesis with potential for high-throughput production. Not dominating due to its relatively niche adoption and limited scalability compared to other methods.
Chip-based Oligonucleotide Synthesis Market Share, By Application, 2024 (%)
| Segments |
Shares (%) |
| Scientific Research |
60% |
| Others |
40% |
- Scientific Research – Dominates with 60% of the market, driven by the vast demand for oligonucleotides in genetic research, diagnostics, and therapeutics. Dominates due to heavy investment in scientific innovation and the increasing importance of oligonucleotides in biological research.
- Others – Accounts for 40% of the market, covering various applications outside of core research, including diagnostics and pharmaceuticals. Gaining momentum as demand in non-research areas grows, particularly in commercial applications and diagnostics.
