U.S. Single-use Bioreactors Market - Databook 2025 to 2034

The global U.S. single-use bioreactors market size surpassed USD 1,842 million in 2024 and is predicted to reach around USD 6,892 million by 2034, registering a CAGR of 15.83% from 2025 to 2034.

Highlights of the U.S. Single-use Bioreactors Market

• By product, the single-use bioreactor systems segment dominated the U.S. single-use bioreactors market in 2024.
• By product, the single-use filtration assemblies segment is expected to grow at the fastest rate in the market during the forecast period of 2025 to 2034.
• By type, the stirred-tank SUBs segment accounted for a considerable share of the market in 2024.
• By type, the wave-induced SUBs segment is projected to experience the highest growth rate in the market between 2025 and 2034.
• By type of cell, the mammalian cells segment dominated the market in 2024.
• By type of cell, the bacterial cells segment is set to experience the fastest rate of market growth from 2025 to 2034.
• By molecule type, the vaccines segment dominated the market in 2024.
• By molecule type, the gene-modified cells segment is anticipated to grow with the highest CAGR in the market during the studied years.
• By application, the research and development (R&D) or process development segment dominated the market in 2024.
• By application, the bioproduction segment dominated the market.
• By end-use, the CROs & CMOs segment maintained a leading position in the market in 2024.
• By end-use, the pharmaceutical & biopharmaceutical companies segment is projected to expand rapidly in the market in the coming years.
• By usage type, the pilot-scale production segment dominated the market in 2024.
• By usage type, the lab-scale production segment will gain a significant share of the market over the studied period of 2025 to 2034.

Industry Valuation and Growth Rate Projection

Single-use bioreactor, also called disposable bioreactor, uses single-use bioreactor bags rather than stainless-steel culture vessels for the producing of numerous biologics. These bioreactors provide numerous advantages over conventional bioreactors, such as cost efficiency, shorter manufacturing timeline, decrease in energy and water consumption, better product outcomes, and low risk of contamination.

What are the Market Trends in the U.S. Single-use Bioreactors Market?

• The trends in the U.S. single-use bioreactors market highlight high demand for therapeutics and biologics, along with improvements in bioreactors thanks to the adoption of sustainable practices.
• The growing demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and other therapeutic proteins, is a major contributor to the single-use bioreactors market.
• Continuous alteration in single-use bioreactor technology, including AI, machine learning, and 3D printing, thus improving their performance and reliability.
• Single-use bioreactors lead to more sustainable practices by decreasing waste, saving water and energy, and removing the demand for cleaning and sterilization, resulting in expense savings.

What Are the Restraints in the U.S. Single-use Bioreactors Market?

• Restraints in the U.S. single-use bioreactors market include issues with raw material sourcing and a lack of developed sustainable options.
• Regulatory bodies across the world impose strict criteria for pharmaceutical quality, efficacy, and safety, which can make it hard to navigate the approval and commercialization procedure for new technologies such as single-use bioreactors.
• The absence of readily available, sustainable options for single-use elements can be a barrier to broader adoption.
• Lack of raw materials, like specific plastics and elements for single-use systems, can disrupt manufacturing timelines and increase expenses.

What Are the Opportunities in the U.S. Single-use Bioreactors Market?

• Opportunities emerging in the U.S. single-use bioreactors market stem from increasing focus on genetic therapies as well as advances related to artificial intelligence being integrated into single-use reactor technologies.
• The growth of cell and gene therapies is boosting the need for scalable and sterile environments offered by single-use systems. These therapies need precise control and can be produced efficiently by utilizing single-use bioreactors.
• Continuous alteration in bioprocessing technologies, like AI integration, real-time monitoring sensors, and 3D printing, is anticipated to improve the performance and reliability of single-use bioreactors.
• Single-use bioreactors are not restricted to biopharmaceutical production and are increasingly used in other fields, such as agriculture, food and beverage, and environmental science.

Recent Developments in the U.S. Single-use Bioreactors Market

• In April 2025, Thermo Fisher Scientific Inc. disclosed the 5L DynaDrive Single-Use Bioreactor (S.U.B.), programmed to meet the evolving demands of modern bioprocessing.
• In September 2024, MilliporeSigma started a single-use reactor to manufacture antibody-drug conjugates (ADCs). Single-use systems use disposable elements that are sterile and pre-validated, decreasing the risk of cross-contamination between batches.