U.S. Business-to-Business E-commerce Market Transforms with AI

The U.S. business-to-business e-commerce market size was estimated at USD 2,101 million in 2024 and is projected to be worth around USD 7,997 million by 2034, growing at a CAGR of 14.3% from 2025 to 2034.

Highlights of the U.S. Business-to-Business E-commerce Market

• By deployment, the intermediary-oriented segment dominated the market in 2023.
• By deployment, the supplier-oriented segment is expected to be the fastest growing during the forecast period.
• By enterprise size, the large enterprise segment dominated the U.S. business-to-business e-commerce market in 2023.
• By enterprise size, the large enterprise segment registered its dominance over the market in 2024.
• By enterprise size, the small & medium enterprise segment is set to be the fastest growing in the forecast period between 2024 and 2033.
• By application, the home & kitchen segment made up the largest share of the U.S. business-to-business e-commerce market in 2023.
• By application, the consumer electronics segment is expected to have the highest compound annual growth rate during the forecast period.

Industry Valuation and Growth Rate Projection

U.S. Business-to-business e-commerce is the purchase and sale of goods and services online between companies through digital platforms, transforming the global trade system, digitizing the purchase and sale process. It is meant for companies such as wholesalers, manufacturers, distributors, and suppliers in various industries, involving high-volume transactions, bulk pricing, catalog customization, and long-term contract negotiations. Modern digitized procurement avenues are driving the U.S. business-to-business e-commerce market so that enterprises can take an online-first approach. Artificial intelligence, machine learning, and blockchain are now serving as catalysts in transforming B2B e-commerce by facilitating decisions based on data, protecting transaction security, and maintaining supply chain visibility in real time. The market is forecasted to see steady growth, carving out the new face of enterprise commerce in the digitalized world.

What Are the Market Trends in the U.S. Business-to-Business E-commerce Market?

The market trends in the U.S. business-to-business e-commerce market are characterized by increasing use of artificial intelligence-based products, the advent of 24/7 virtual assistance, and supply chain optimization using these technologies.

• AI-Powered Personalization: Services recommending products and providing tailor-made shopping experiences.
• Virtual Assistance Round the Clock: Just-in-time support to customers.
• Visual and Smart Search: Search to discover products and enrich the user experience.
• Supply Chain Optimization: Figure out the necessity and stock up.
• Content and Pricing Automation: Dynamic pricing, fraud detection, automated product descriptions, marketing phrases.

What Are the Restraints in the U.S. Business-to-Business E-commerce Market?

Security concerns, data privacy, regulatory landscape are major factors hampering the growth of the U.S. business-to-business e-commerce market.

• Data Privacy: Played by customer concerns about data usage and strict laws governing data protection.
• Cybersecurity Risk: Epidemic-level data breach and attacks.
• High Opening Cost: Initial setup and labor of skilled AI and infrastructure costs deter smaller players.
• Complex Regulatory Landscape: Going through global and local laws and regulations of data governance can stand in the way of AI adoption.
• ROI Risk: Companies are faced with the question of whether the solution is profitable enough to justify its investment and maintenance.

What Are the Opportunities in the U.S. Business-to-Business E-commerce Market?

Key opportunities in the U.S. business-to-business e-commerce market are driven by tailored customer insights and predictive AI analysis deployed for planning.

• Personalized Customer Journeys: AI promotes the formation of customized experiences.
• Prices and Promotions Changes: AI analyzes real-time data, applying the best price or best offer.
• Predictive Inventory Planning and Demand: AI analyses demand for the product and plans for inventory accordingly.
• Marketing Automation Agitated by Artificial Intelligence: AI helps companies market better.
• Efficiency of Operations & Cost Savings: Automation of repetitive work leads to reductions in costs and gains in productivity and enhanced decision-making.

Recent Developments in the U.S. Business-to-Business E-commerce Market:

• In June 2025, EPWK International, a leading force in China's creative crowdsourcing industry, launched its English site, marking a pivotal moment for the company's global expansion.
• In April 2025, Koloni and Virtual.com are partnering to launch North America's largest parcel locker network, deploying over 5,000 locker locations across the US and Canada within 12 months.

U.S. Business-to-Business E-commerce Market Companies:

• Amazon Business
• Alibaba Group
• eBay Business Supply
• ThomasNet
• Wayfair Professional
• Shopify Plus
• NuORDER
• Joor
• Newegg Business
• B2B Wholesale Central

U.S. Business-to-Business E-commerce Market Segmentation:

By Deployment

• Supplier-Oriented
• Buyer-Oriented
• Intermediary-Oriented

By Enterprise Size

• Small & Medium Enterprise
• Large Enterprise

By Application

• Home & Kitchen
• Consumer Electronics
• Industrial & Science
• Healthcare
• Clothing
• Beauty & Personal Care
• Sports Apparel
• Books & Stationery
• Automotive
• Others